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Interactive Protein Manipulation

@inproceedings{Kreylos:2002:IPM,
title="Interactive Protein Manipulation",
booktitle="Proceedings of the 2002 UC Davis Student Workshop on Computing, TR CSE-2002-28",
author="Oliver Kreylos AND Bernd Hamann AND Nelson Max AND Wes Bethel AND Silvia Noemi Crivelli ",
year="2002",
publisher="University of California, Davis",
address="Davis, California",
abstract="One of the grand challenges in computational biology is the prediction of the three-dimensional structure of a protein, which determines its function, from its chemical makeup alone. A protein’s primary structure, i. e., its amino acid sequence, is directly encoded in its DNA sequence,which is a purely one-dimensional structure that does not directly encode a three-dimensional shape. It is commonly believed that the “native” shape of a protein is the one corresponding to the global minimum of its internal energy; thus, the protein folding problem has been treated as an optimization problem in recent years. It is important to start solving any optimization problem from a “good” set of initial configurations that allow the optimization code to, ideally, search the complete optimization space for a global minimum. Our work focuses on providing an interactive, visual tool to rapidly create many initial configurations for a given amino acid sequence, which are then used as input for an optimization algorithm.",
}
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